Name: Musk Ketone CAS# 81-14-1
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Musk Ketone CAS# 81-14-1

Product Details

Musk Ketone CAS# 81-14-1

Musk Ketone is an important synthetic fragrance compound with the molecular formula C₁₄H₁₈N₂O₅ and a molecular weight of 294.303. It appears as pale yellow crystals, typically in powder or flake form, and is characterized by a sweet, animal-like musk aroma that is soft and long-lasting.

Musk Ketone is insoluble in water and ethanol, but readily soluble in benzyl benzoate, animal oils, and essential oils. It has a melting point of 135–139 °C, a density of approximately 1.2 ± 0.1 g/cm³, and a boiling point of 369.0 ± 42.0 °C at 760 mmHg. Its flash point is 153.2 ± 20.7 °C.

Product Name:	Musk ketone
Synonyms:	2-Acetyl-5-tert-butyl-4,6-dinitro-1,3-dimethylbenzene;3',5'-Dinitro-4'-tert-butyl-2',6'-dimethylacetophenone;3, 5-Dinitro-4-t-butyl-2, 6-dimethylacetophenone;Ketone Moschus,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Musk ketone;Musk ketone,4-tert-Butyl-2,6-dimethyl-3,5-dinitroacetophenone, Ketone Moschus;Musk ketone 0;Ketone Moschus >=97.0% (N);1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl)-ethanon
CAS:	81-14-1
MF:	C14H18N2O5
MW:	294.3
EINECS:	201-328-9
Product Categories:	PP;KetonesAlphabetic;Analytical Standards;AromaticsAnalytical Standards;Chemical Class;Life Sciences Standards;Aromatic Acetophenones & Derivatives (substituted);M;METI - MZChromatography;Natural Compounds;Natural CompoundsAnalytical Standards;Nitro CompoundsChemical Class;OtherMore...Close...;Cosmetics;Food & Feed ADDITIVES;Organics
Mol File:	81-14-1.mol

Musk ketone Chemical Properties

Melting point	134-137 °C
Boiling point	436.08°C (rough estimate)
Density	1.2051 (rough estimate)
Vapor pressure	0.001Pa at 25℃
Refractive index	1.5110 (estimate)
Fp	2 °C
Storage temp	2-8°C
Solubility	DMSO : 250 mg/mL (849.47 mM; Need ultrasonic)
Form	Solid
Color	White to off-white
Odor	at 10.00 % in benzyl benzoate. fatty musk soapy dry floral powdery
Odor Type	musk
Biological source	synthetic
Water Solubility	Insoluble (<0.1 g/100 mL at 20 ºC)
BRN	2062638
Stability	Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey	WXCMHFPAUCOJIG-UHFFFAOYSA-N
LogP	4.24 at 25℃
CAS DataBase Reference	81-14-1(CAS DataBase Reference)
NIST Chemistry Reference	2,6-Dimethyl-3,5-dinitro-4-t-butylacetophenone(81-14-1)
EPA Substance Registry System	Musk ketone (81-14-1)

Product Usage

Musk Ketone is widely used as an important synthetic fragrance and fixative. In the flavor and fragrance industry, it is commonly used in the formulation of various fragrance blends to provide products with a distinctive and long-lasting musky scent, particularly in sweet, oriental, and heavy fragrance types.

In the cosmetics industry, it is frequently incorporated into perfumes, powders, creams, and similar products. It not only enhances the overall fragrance profile but also helps the scent remain on the skin for a longer period.

In addition, although its use in the pharmaceutical field is limited due to potential toxicity and environmental concerns, pharmacological studies indicate that it can stimulate the central nervous system, respiratory center, and heart. It may also promote glandular secretion, dilate coronary arteries to increase coronary blood flow, and contribute to improved blood circulation, reduction of swelling, and relief of pain.